Familial adenomatous polyposis (FAP) heriditary colon cancer
Conditions
Interventions
Both interventions are standard care for detecting adenomas.
1. Virtual chromoendoscopy
2. Dye chromoendoscopy
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Diagnosis of FAP - Genetic diagnosis: proven APC germline mutation - Clinical diagnosis: >100 colorectal adenomas in combination with a positive family history of FAP Have an ileal-pouch anal anastomosis (IPAA) - After primary proctocolectomy or - secondary protectomy after initial colectomy with ileorectal or ileosigmoidal anastomosis (IRA/ISA) Age >= 18 years.
Exclusion criteria
Exclusion criteria: Allergy to indigo carmine (fluid which is used with dye chromoendoscopy). Patients who are unwilling or unable to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is the detection of clinical relevant adenomas (>= 5mm) in the ileal pouch. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include: - Detection of advanced neoplasia in the ileal pouch, defined by advanced adenoma (>=10mm and/or and adenoma with high-grade dysplasia) or cancer. - Detection of adenomas 1-4mm, 5-9mm and >=10mm both in the pouch body and rectal remnant with WLE, NBI and dye-based chromoendoscopy - Number of performed polypectomies - Chosen interval for next surveillance endoscopy - Insight Polyposis Staging System (IPSS) score (10) - Duration of examination - Incidence of endoscopy-related complications | — |
Countries
Netherlands
Outcome results
None listed