Detecting aneurysmal instability by linking imaging and genetics

Detecting aneurysmal instability by linking imaging and genetics - DETAILING

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53244

Enrollment

Registered

2023-06-20

Start date

2024-03-19

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

'cerebral aneurysm' 'Intracranial aneurysm' brain aneurysm

Interventions

none

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Have an unruptured intracranial aneurysm Need surgical clipping to treat the intracranial aneurysm Age 18 years or older

Exclusion criteria

Exclusion criteria: Participant is unable to undergo an MRI scan in both the 7 Tesla or 3 Tesla MRI machine

Design outcomes

Primary

Measure	Time frame
Main parameters in this study are: 1. Genetic parameters: gene expression (transcripts per million) of all genes specific to each arterial cell-type (detectable cell-types expected are vascular endothelial cells, vascular smooth muscle cells, vascular fibroblasts). 2. Aneurysm hemodynamic parameters 4D MR flow parameters a. mean flux (ml), b. stroke volume (ml per s), c. derived biomechanical parameters including pulsatility index, arterial distensibility (mm Hg-1), wall shear stress (Pa) and oscillatory shear index. These will be determined both in the aneurysm and in the feeding arteries. 3. Aneurysm configuration parameters: aneurysm size (length, width (mm), aneurysm volume (ml) and aneurysm irregularity (more complex geometric definitions as surface area, eccentricity, compactness, shape index and curvedness). Main outcome measurements are: IA size, IA rupture risk assessment by the PHASES score.1	—

Measure

Time frame

Main parameters in this study are: 1. Genetic parameters: gene expression (transcripts per million) of all genes specific to each arterial cell-type (detectable cell-types expected are vascular endothelial cells, vascular smooth muscle cells, vascular fibroblasts). 2. Aneurysm hemodynamic parameters 4D MR flow parameters a. mean flux (ml), b. stroke volume (ml per s), c. derived biomechanical parameters including pulsatility index, arterial distensibility (mm Hg-1), wall shear stress (Pa) and oscillatory shear index. These will be determined both in the aneurysm and in the feeding arteries. 3. Aneurysm configuration parameters: aneurysm size (length, width (mm), aneurysm volume (ml) and aneurysm irregularity (more complex geometric definitions as surface area, eccentricity, compactness, shape index and curvedness). Main outcome measurements are: IA size, IA rupture risk assessment by the PHASES score.1

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Countries

Netherlands

Contacts

Public ContactY.M. Ruigrok

Universitair Medisch Centrum Utrecht

trialbur@umcutrecht.nl0887558350

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Mar 20, 2026