Comel-Netherton Syndrome Netherton Syndrome
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
16 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Diagnosed with NS by an expert professional - Aged 16 years or above - Able to read patient information, fill out questionnaires and provide informed consent
Exclusion criteria
Exclusion criteria: - Systemic antibiotics within the previous 4 weeks - Topical antibiotics within the previous 7 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - IgG antibody levels against S. aureus antigens, and a panel of other bacterial antigens (e.g. Pseudomonas aeruginosa, Streptococcus pneumoniae) measured in serum of NS patients using a Luminex assay, and compared to IgG antibody levels in healthy S. aureus carriers and non-carriers, AD patients and EB patients. - A list of S. aureus proteins produced in the skin of NS patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Differences in IgG and IgG4 antibody levels in NS patients over time. - Identification and characterization of S. aureus (skin and nose) in NS patients. | — |
Countries
Netherlands
Outcome results
None listed