Neural plasticity and recovery after early and intensive upper extremity motor training in people with cervical spinal cord injury.

Neural plasticity and recovery after early and intensive upper extremity motor training in people with cervical spinal cord injury. - REPAIR-SCI

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON53224

Enrollment

Registered

2023-04-03

Start date

2024-10-06

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Cord Injury tetraplegia

Interventions

The intervention group receives 6 hours of motor training each week. This involves active and targeted motor training of all affected muscles below the injury level in the context of functional acti

Eligibility

Age

16 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Traumatic or non-traumatic C-SCI in the preceding 13 weeks; age over 16 years; have an incomplete SCI or an AIS A SCI with zones of partial motor paralysis (as defined by the International Standards for the Neurological Classification of SCI (ISNCI) and medically stable.

Exclusion criteria

Exclusion criteria: Exclusion criteria: SCI with ASIA Impairment Scale (AIS) A without zones of partial preservation (decided based on former studies [58]) and expertise of the team; SCI with any significant medical condition that could prevent the person from participating. In order to ensure TMS measurement can be performed, patients will only be included in this WP if they have a positive response to motor evoked potential measurement (MEP+) [59] and will be excluded in the presence of contraindications for TMS application such as epilepsy, metal implants in the brain, defibrillator, pacemaker and pregnancy.

Design outcomes

Primary

Measure	Time frame
Central plasticity via: Single pulse TMS (resting motor threshold) & compound motor action potential 8 weken after randomisation	—

Secondary

Measure	Time frame
Klinische maten: Upper Extremity Motor Score, Spinal Cord Independence Measure (SClM-zelfzorg); Van Lieshout Test (VLT); Grades redefined assessment of strength sensibility and Prehension (GRASSP); Hand-Held Dynamometrie; accelerometrie (sessie densiteit: actievetherapietijd/sessie lengte); ervaring moeilijkheid en ervaring intensiteit. Centrale plasticiteit: Paired pulse TMS: (SICI; LICI; SICF); perifere plasticiteit: NET (Nerve excitability testing) en MScanFit MUNE (Compound muscle action potential (CMAP).	—

Measure

Time frame

Klinische maten: Upper Extremity Motor Score, Spinal Cord Independence Measure (SClM-zelfzorg); Van Lieshout Test (VLT); Grades redefined assessment of strength sensibility and Prehension (GRASSP); Hand-Held Dynamometrie; accelerometrie (sessie densiteit: actievetherapietijd/sessie lengte); ervaring moeilijkheid en ervaring intensiteit. Centrale plasticiteit: Paired pulse TMS: (SICI; LICI; SICF); perifere plasticiteit: NET (Nerve excitability testing) en MScanFit MUNE (Compound muscle action potential (CMAP).

—

Countries

Belgium, Netherlands

Contacts

Public ContactI Hrycyk

Universiteit Hasselt

imke.hrycyk@uhasselt.be003211268111

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)