Healthy tendon and injured anterior cruciate ligament protein synthesis Tendon and ligament recovery
Conditions
Interventions
All participants will be randomly assigned to the intervention or control
group. The intervention group will receive:
• Collagen supplementation: The vitamin C-containing collagen supplement (20 g
p
Sponsors
HAN University of Applied Sciences
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Planned for ACL reconstruction with hamstring or quadriceps autograft Age >=18 and =18.5 and
Exclusion criteria
Exclusion criteria: • Blood donation during the study period or during the last 2 months • Pregnancy • Third generation oral contraceptives • Consumption of >21 alcoholic beverages per week • Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications). • Regular use of protein or other nutritional supplements (including vitamins). • Reported slimming or medically prescribed diet • Use of antibiotics in the past month • Current participation in another biomedical research study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess the impact of collagen supplementation on healthy tendon protein synthesis in otherwise healthy individuals (18 - 40 y) scheduled for ACL-surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess the impact of collagen supplementation on injured ligament and healthy muscle protein synthesis, based on ligament and muscle tissues that also become available during the ACL-surgery. | — |
Countries
Netherlands
Contacts
Public ContactLPM Hilkens
HAN University of Applied Sciences
Outcome results
None listed