The perioperative microbiota composition in colorectal surgery patients receiving oral antibiotics or no oral antibiotics

The perioperative microbiota composition in colorectal surgery patients receiving oral antibiotics or no oral antibiotics - SELECT-microbiota

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53205

Enrollment

120

Registered

2023-10-18

Start date

2023-09-01

Completion date

Unknown

Last updated

2025-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative microbiota

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients 18 years and older Dutch or English speaking Candidate for elective laparoscopic/open colorectal surgery with a primary anastomosis Undergoing a right hemicolectomy, sigmoid resection or laparoscopic low anterior resection (LAR) Biopsy-proven colorectal carcinoma (or a high index of suspicion of carcinoma on biopsy) with no imaging signs of distant metastasis

Exclusion criteria

Exclusion criteria: No primary anastomosis or deviating stoma Recent abdominal surgery (

Design outcomes

Primary

Measure	Time frame
The primary objective of this study is to evaluate the differences in microbiome composition and diversity between different microbiota samples. To achieve this objective, we will employ various statistical tests, including t-tests or ANOVA, to compare the alpha and beta diversity measures between microbiota samples.	—

Secondary

Measure	Time frame
1. Comparison of peri-operative changes in microbiota composition between colon cancer patients receiving preoperative oral antibiotic prophylaxis with or without amphotericin B. 2. Correlation between the gut microbiota composition and specific microbiota on site of an occurring post-operative infection. 3. Comparison of rectal and anastomotic microbiota composition for right and left sided colon resections	—

Measure

Time frame

1. Comparison of peri-operative changes in microbiota composition between colon cancer patients receiving preoperative oral antibiotic prophylaxis with or without amphotericin B. 2. Correlation between the gut microbiota composition and specific microbiota on site of an occurring post-operative infection. 3. Comparison of rectal and anastomotic microbiota composition for right and left sided colon resections

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Countries

Netherlands

Outcome results