Sarcopene obesitas Sarcopenic obesity
Conditions
Interventions
The 2EAT dietary intervention includes dietary counselling focussed on
behavioural change, and a diet with an energy restriction of 500 kcal and
increased protein intake based towards 1.2 g/kg/day (
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Aged 55 or older Are obese: have a BMI of >30 kg/m2 or BMI >27 kg/m2 and waist circumference >88 cm (women) or >102 cm (men) Living independently (not in a health facility) The willingness that the general practitioner will be notified of study participation Written informed consent Willingness to comply with the protocol Consent of the study physician
Exclusion criteria
Exclusion criteria: Inability to understand the Dutch language Cognitive impairment (MMSE 1 week (in phase 1) or > 3 weeks (in phase 2) The health conditions below will be assessed by the study physician. When a condition interferes the dietary treatment or if the diet worsens the participants health it counts as exclusion criteria: Diagnosed with unstable coronary heart disease (CHD), decompensated heart failure, uncontrolled hypertension or uncontrolled arrhythmias (e.g. heart failure NYHA >3) Diagnosed degenerative neurocognitive disorders Diagnosed with renal failure COPD GOLD >3
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the change in plant-based protein intake compared to animal protein intake between baseline and three (primary) and six-months intervention (3-day dietary record). | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight loss; Skeletal muscle mass; Exploratory parameters: Muscle strenth: hand grip strength Physical performance: 400m walk test, short physical performance battery Body composition: fat free mass, total body water, body weight, waist circumference, BMI Metabolic outcomes: blood pressure, heart rate, lipid profile, blood glucose (HOMA-index), inflammation (CRP), nutritional status (vitamin B12 and heamoglobin) Quality of live Vitality Nutritional adequacy Behavioral change Process evaluation of the dietary treatment | — |
Countries
Netherlands
Outcome results
None listed