kidney transplantation, graft survival
Conditions
Interventions
Not applicable.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Kidney transplant recipient Age 18 - 80 years
Exclusion criteria
Exclusion criteria: No informed consent Infection in the past four weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The trained immunity profile of monocytes from renal transplant patients. Before, one week after, and three months after renal transplantation, blood is drawn from patients and circulating monocytes are isolated to examine the activity, transcriptome, and epigenome of these monocytes. 2. The association between trained immunity and renal transplant survival. The association between the trained immunity profile as measured in (1) and graft survival in the first two years after transplantation is investigated. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The association between trained immunity and inflammation and tissue damage. The association between the trained immunity profile as measured in (1) and markers for tissue damage and systemic inflammation is investigated. 2. The association between trained immunity and the concentration of immunosuppressive drugs in the blood of patients. 3. The association between trained immunity and the amount of white blood cells and subsets of white blood cells. | — |
Countries
Netherlands
Contacts
Public ContactR Duivenvoorden
Radboud Universitair Medisch Centrum
Outcome results
None listed