The research will be conducted with healthy volunteers and no patients are involved.
Conditions
Interventions
In the S(+)-ketamine session, subjects will receive an intravenous (IV) administration of a continuous infusion of 20 mg /h (per 70 kg) for 1 hour, followed by an infusion of 30 mg /h (per 70 kg) for
session, participants will receive an IV administration of 50ml of saline solution.
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Healthy male or female volunteers; 2. Age: 18 - 40 years; 3. Body mass index < 30 kg/m2; 4. Able to give informed consent; 5. Be able to speak and understand English.
Exclusion criteria
Exclusion criteria: 1. Known or suspected neuromuscular or a (family) history of any neuromuscular disease; 2. A history of allergic reaction to food or medication including study medication;3. Any current or previous medical (including high blood pressure), neurological or psychiatric illness (including a history of anxiety);4. Alcohol abuse (> 21 units/week);5. Illicit drug use in the past 30 days before inclusion;6. Pregnancy or lactation;7. Participation in any medical or drug trial in the month prior to the current study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measures are the neural and behavioral effects of S-ketamine relative to placebo. Specifically, we examine the neural effects of S-ketamine on event-related potentials (ERPS) in a sensory suppression task and in a sustained attention task. Additionally, we examine the effects of S-ketamine on perception of body perception and agency, feelings of feelings of embodiment and perception of heart rate, through behavioral-experimental tasks and measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome measures of this study are the effects of S-ketamine on subjective perception, measured by questionnaires and an interview; the relationship between the subjective measures and neural and behavioral effects; and the relationship between personality factors and subjective effects. | — |
Countries
Netherlands
Contacts
Public ContactMvE Michiel van Elk
Universiteit Leiden
Outcome results
None listed