hypoxie hypoxia oxygen deficiency
Conditions
Interventions
None listed
Sponsors
TNO
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • You are healthy (as defined in the criteria below). • You are between 18 and 50 years old. • You don't smoke. • You are not pregnant. • You have a BMI between 18 and 25 kg/m2. BMI formula: weight in kilograms / (height in meters * height in meters). • You do not drink alcohol on the evening before the start of the test day. • You have not used any drugs in the past 3 months. • You are prepared to undergo a medical examination, consisting of a short physical examination, completing a few questionnaires and a short ECG. • You have no cardiovascular disorders. • You are not familiar with psychiatric and/or neurological disorders. • You do not have chronic anemia. • You are not claustrophobic and able to spend an hour in a confined space. • You have not donated blood in the past 72 hours • You are not overly sensitive to airsickness (a form of motion sickness, where you become ill from a flight). • You have not been at altitude (>2000m) for more than a week in the past 3 months. • You accept that the collected data will be stored and processed in encrypted form, archived for at least 10 years and possibly published.
Exclusion criteria
Exclusion criteria: none, other than not fulfilling the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is the SpO2 in the retina at different simulated heights. The data is collected with the adapted fundus camera. The criterion validity of the data is assessed by comparing the data with data measured with a reference method (finger NIRS, WristOx 3150 with 8000SM-WO2 soft sensor, Nonin Medical Inc, Plymouth, USA). | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary outcome measure is heart rate (beats per minute) measured in the retina. The twilight lighting conditions may make it possible to distill the heart rate from data measured with the modified fundus camera. The validity of the data is again assessed by comparing it with data measured with the above reference method (finger NIRS, WristOx 3150 with 8000SM-WO2 soft sensor, Nonin Medical Inc, Plymouth, USA). | — |
Countries
Netherlands
Outcome results
None listed