Het onderzoek wordt bij gezonde proefpersonen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvatten voor verklaringsmodellen en therapeutische interventies voor aandoeningen waarbij jeuk een symptoom is. Not applicable
Conditions
Interventions
Positive expectations will be induced by means of verbal suggestions in the
verbal suggestion condition.
Expectations
Itch
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Between 18 and 35 years old; good understanding of written and spoken Dutch
Exclusion criteria
Exclusion criteria: Refusal to give written informed consent; severe somatic or psychological morbidity (e.g. heart and lung diseases, or DSM-IV psychiatric disorders) that would adversely affect participant*s safety or study protocol; current chronic itch or pain complaints; current use of analgesics, anti-inflammatory drugs, antihistamines, antibiotics; pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is self-reported mean itch during histamine iontophoresis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study outcomes include wheal size, flare response, skin temperature and self-reported skin condition following histamine iontophoresis, as well as scratching behaviour. In addition, effects on positive and negative affect and generalized expectations will be explored. The possible influence of psychological parameters on outcomes will be explored as well. | — |
Countries
The Netherlands
Outcome results
None listed