Beroerte brain infarction Stroke
Conditions
Interventions
The intervention group will undergo immediate IAT using a stent retriever, as
recommended by the steering committee. The standard care group will receive IVT
0.9 mg/kg with a maximum dose of 90 mg i
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All subjects enrolled in the MR CLEAN-NO IV trial. For patients that are also invited for the follow-up MRI scan, the following additional criteria apply: - 24-hours follow-up MRI scan available. - Patiënt is able to come to the Amsterdam UMC by themselves or supported by family or friends.
Exclusion criteria
Exclusion criteria: Only for patients that are invited to the follow-up MRI scan the following exclusion criteria apply: - Default research screening associated with a MRI scan (see attachment 'vragen testpersonen 3TMRI_NL') - Patiënt who are mobility impaired, as the study requires them to travel to the hospital.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes are (1) the score on the modified Rankin Scale (mRS), as functional outcome measure from 0 (no symptom) to 6 (death), at 18, 24, 30 or 36 months after AIS and (2) long-term evolution of stroke lesions through acquisition of a 24-month (range 18 to 36 months) follow-up MRI scan. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes include the quality of life, Barthel index, major vascular events, and costs related to stroke, both medical costs and productivity loss, at 18, 24, 30 or 36 months. In addition we aim to include deep leaming reconstruction, in which common image describïng parameters such peak signal to noise ratio (pSNR), structural similarity (SSIM) and sharpness will be evaluated. | — |
Countries
Netherlands
Outcome results
None listed