inflammatory bowel disease, Crohn's disease, ulcerative colitis
Conditions
Interventions
Not applicable.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
16 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the IBD-discordant and IBD-concordant twins or multiples: - Born as a sibling of, either a monozygous or dizygous, twin pair or multiplex - One or more twin-siblings or multiples are affected with IBD, i.e. CD, UC or IBD unspecified (self-reported diagnosis, to be confirmed during the study by clinical, endoscopic or histological reports from the treating physician) - Age: 16 years and olderIn order to be eligible to participate in this study, a subject must meet all of the following criteria for the unaffected controls (preferably twins or multiples): - None of the siblings of the twin are affected with IBD, i.e. CD, UC or IBD unspecified - Age: 16 years and older
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - No consent to participate in the study. - Unable to read or understand the Dutch language.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparisons will be made between siblings of twin pairs and between IBD patients and non-IBD controls. Amongst others, changes in immune parameters in the mucosal and peripheral blood compartment, gut and oral microbiome, epithelium and mucus barrier function, and the metabolome will be studied. In addition, correlations between demographic, environmental and nutritional factors will be made, and quality of life an symptom fluctuations prior to or during IBD will be studied. | — |
Secondary
| Measure | Time frame |
|---|---|
| See above. | — |
Countries
Netherlands
Contacts
Public ContactS.L. Dijkstra
Universitair Medisch Centrum Utrecht
Outcome results
None listed