osteoarthritis
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Diagnoses of hand OA, rheumatoid arthritis, or psoriatic arthritis according to recognised classification criteria sets 2. Presence of an inflamed interphalangeal or MCP joint for which the treating rheumatologist has proposed treatment with an intra-articular injection with corticosteroids. 3. Patients should be 40 years of age or older.
Exclusion criteria
Exclusion criteria: 1. Patients that had an intra-articular injection with corticosteroids, an operation or an important trauma in the same joint less than 12 weeks before the intended injection 2. The presence of a chronic inflammatory disease (other than OA, rheumatoid arthritis or psoriatic arthritis), such as poly-articular gout 3. Contra-indication for an intra-articular injection such as anti-coagulant (vitamin K antagonist) use that can*t be discontinued.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • The percentage of study joints in which a successful aspiration is performed. | — |
Secondary
| Measure | Time frame |
|---|---|
| • The volume of the obtained synovial fluid collections (µl). • To analyse the presence of cytokines (such as IL-1, IL-6, IL-8, TNF-a), of immune cells (neutrophils, macrophages, lymphocytes) and adipokines and lipid mediators in the synovial fluid. • The relation between the US effusion score and volume of synovial fluid that is aspirated from the study joint. Other study parameters • Association of physical and ultrasound inflammatory/structural features and the ability to obtain synovial fluid (i.e. obesity, big structural abnormalities, such as osteophytes or joint space narrowing) • To investigate whether there is a difference in feasibility, amount of synovial fluid and analyses between hand OA and inflammatory arthritis (rheumatoid arthritis and psoriatic arthritis) | — |
Countries
Netherlands
Outcome results
None listed