Preclinical Alzheimers disease
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Label of subjective memory complaints (i.e. no diagnosis of dementia, mild cognitive impairment, psychiatric or neurological disorder explaining cognitive complaints). - Signed informed consent projects P2005_160, P2000_211, P2016_061 or P2016_409. - Age * 45 year.
Exclusion criteria
Exclusion criteria: - Insufficient knowledge of Dutch language. - Major psychiatric disorder, such as psychosis, schizophrenia, severe personality disorder or depression with vital signs, abuse of alcohol or other substances. - Neurological disorder such as Parkinson*s disease, symptomatic stroke, mental retardation. - Acquired Immune Deficiency Syndrome (AIDS) or Human Immunodeficiency Virus (HIV).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical progression, i.e. progression to a clinical diagnosis of MCI or dementia. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Decline in cognitive functioning on neuropsychological testing (i.e. memory, language, visuospatial functioning, attention, executive functioning etc). - Decline in daily functioning as measured using the Amsterdam IADL questionnaire - Amyloid-positivity (as measured using CSF biomarkers and/or amyloid-PET) as an endophenotype for AD. | — |
Countries
Netherlands
Contacts
Public ContactA.C. van Harten
Amsterdam UMC
Outcome results
None listed