precancerous lesions of the stomach Premalignant gastric lesions Premalignant gastric lesions
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients with a previous diagnosis of atrophic gastritis, intestinal metaplasia and/or dysplasia of the gastric mucosa Age 18 years or older
Exclusion criteria
Exclusion criteria: Previous upper gastrointestinal surgery Previous diagnosis of gastric cancer or any other maligancy not being in remission Subjects with severe concomittant illness limiting their expected survival to less than 2 years Subject with portal hypertension Subjects with proven CDH1 mutation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression of premalignant gastric lesions, both in terms of distribution and severity. | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of the risk factors, which play a role in progression or regression of premalignant gastric lesions. Evaluation of the existing guideline for premalignant lessions of the stomach. Evaluation of the correlation between serum pepsinogen I, II and gastrin and the histological severity and extent and intragastric distribution of premalignant gastric lesions. To assess the involvement of genetic risk factors on oxidative dammage induced by innate immune cells, imuune cell function, and the eradication of Helicobacter pylori. Evaluation of current guidelines | — |
Countries
Netherlands
Contacts
Public ContactV.M.C.W. Spaander
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed