Epilepsy - Convulsions
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Medically refractory epilepsy Diagnostic workup up till that moment has not led to decline the patient for resective epilepsy surgery A suspected (neo-)cortical seizure focus at the surface of the brain Planned implantation of intracranial electrodes Incapacitating epilepsy or seizures (no absolute minimal frequency) Minimum age 18 years
Exclusion criteria
Exclusion criteria: For patients • Patients with (co-existent) psychogenic, non-epileptic attacks, or low IQ (below 70). • (post-ictal) psychosis during the registration period will lead to exclusion from the research., For both patients as well as for controls: 1. Head injury with intracranial abnormalities (cerebral contusion) 2. Stroke (hemorrhagic or ischemic) 3. Metallic prostheses or pacemaker in the subject*s body or other contra indications for MRI. , For the healthy subjects only: 1. Any neurological or psychiatric disease 2. Use of medication affecting the central nervous system
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter will be the topographic characterization of the neural activity during the processing of different sensory stimuli and the performance of attention as well as short-term memory tasks. The neural activity will be measured by ECoG and by functional magnetic resonance imaging (fMRI) | — |
Secondary
| Measure | Time frame |
|---|---|
| N.A. | — |
Countries
Netherlands
Outcome results
None listed