hand osteoarthrosis osteoarthritis in de hand
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: •Symptomatic *primary* hand OA as diagnosed by a rheumatologist from the outpatient rheumatology clinic of the LUMC
Exclusion criteria
Exclusion criteria: •Any other pathological condition that could explain the existing symptoms, like tendinitis, carpal tunnel syndrome, surmenage, fibromyalgia, arthritis due to a primarily inflammatory rheumatic disease. •*Secondary* OA, including 1) inflammatory joint diseases, like rheumatoid arthritis, psoriatic arthritis, spondylarthropathies and current sarcoidosis, 2) bone diseases such as osteitis deformans and osteochondritis, 3) intraarticular fractures, 4) certain metabolic diseases associated with joint disease such as hemochromatosis, Wilson*s disease and ochronosis, 5) endocrine disease like acromegaly, 6) major congenital or developmental diseases and bone dysplasias, 7) major local factors such as hypermobility, 8) severe (tophous) gout. •Inability to understand the Dutch language, Additional exclusion criterion solely for the Bioelectrical Impedance Analyses (BIA) part of the physical exam (patients who are excluded for the BIA, will not perform this part of the physical exam, but can still participate in all the other components of HOSTAS): - The presence of a pacemaker or subcutaneous cardio defibrillator. , Additional exclusion criteria for patients who undergo MRI for the study: - The presence of metal in the body: pacemaker or subcutaneous cardio defibrillator, vascular clips on cerebral vessels, metallic splinters in the eye, not removable listening aid, not removable neurostimulator, hydrocephaluspump, dentures fixated by magnets, intra-uterine device - Allergy for MRI contrast agents - Impaired renal function - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This is an descriptive study: 1. Expositions of interest are: age, sex, profession, hand strength, familial/genetic factors, overweigth, symptoms, findings from physical examination, radiological variables, like joint space narrowing, osteophytes, erosions, and MRI variables, like bone marrow lesions, effusion 2. Outcomes are: diagnosis hand osteoarthritis, disease course, both clinically as well as radiologically, over time, use of certain treatment modalities (painkillers, splints, etc.) 3. Determinants going together with different sub-sets of hand osteoarthritis, like erosions, nodes, thumb base involvement, can be used as exposition as well as outcome in the study. | — |
Countries
Netherlands
Outcome results
None listed