MeninGene

Nationwide prospecbve study on cornmunity-acquired bacterial meningitis. from genetics to therapy - MeninGene

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53059

Enrollment

3000

Registered

2013-02-22

Start date

2013-04-29

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial meningitis Bacterial infection of the membranes lining the brain

Interventions

None listed

Eligibility

Age

16 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age 16 or olderBacterial meningitis defined by positive bacterial culture or PCR of cerebrospinal fluid

Exclusion criteria

Exclusion criteria: Neurosurgical operation in the month previous to the meningitis episode Head trauma in the month previous to the meningitis episode Presence of neurosurgical devices in the central nervous system such as cerebrospinal fluid catheters or deep brain neurostimulator/

Design outcomes

Primary

Measure	Time frame
Online case-record forms will be used to collect data on patient history, symptoms and signs on admission, laboratory findings at admission, treatment (including adjunctive treatment), clinical course, outcome and neurological findings at discharge. Severity and clinical deterioration will be evaluated. Data on complications will be collected according to predefined criteria. Results of neuroimaging will be collected. At discharge, all patients undergo a neurological examination performed by a neurologist, and the outcome is graded according to the Glasgow outcome scale. A score of 1 on this scale indicates death; a score of 2, a vegetative state (the patient is unable to interact with the environment); a score of 3, severe disability (the patient is unable to live independently but can follow commands); a score of 4, moderate disability (the patient is capable of living independently but unable to return to work or school); and a score of 5, mild or no disability (the patient is able to return to work or school). A favourable outcome will be defined as a score of 5, and an unfavourable outcome as a score of 1 through 4. The Glasgow outcome scale is a welI-validated instrument with good inter-observer agreement.	—

Measure

Time frame

Online case-record forms will be used to collect data on patient history, symptoms and signs on admission, laboratory findings at admission, treatment (including adjunctive treatment), clinical course, outcome and neurological findings at discharge. Severity and clinical deterioration will be evaluated. Data on complications will be collected according to predefined criteria. Results of neuroimaging will be collected. At discharge, all patients undergo a neurological examination performed by a neurologist, and the outcome is graded according to the Glasgow outcome scale. A score of 1 on this scale indicates death; a score of 2, a vegetative state (the patient is unable to interact with the environment); a score of 3, severe disability (the patient is unable to live independently but can follow commands); a score of 4, moderate disability (the patient is capable of living independently but unable to return to work or school); and a score of 5, mild or no disability (the patient is able to return to work or school). A favourable outcome will be defined as a score of 5, and an unfavourable outcome as a score of 1 through 4. The Glasgow outcome scale is a welI-validated instrument with good inter-observer agreement.

—

Countries

Netherlands

Contacts

Public ContactD. van de Beek

Amsterdam UMC

meningitis@amsterdamumc.nl0205664586

Outcome results