influenza pneumonia
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
No minimum to 11 Years
Inclusion criteria
Inclusion criteria: - Admitted for SARI, defined as respiratory tract infection necessitating hospitalization. - Tested qRT-PCR positive for RSV, HMPV, PIV and/or Influenza A+B (co-infection allowed) - Written Informed consent obtained For paramyxovirus infections: Children in the age range of new-born until two years hospitalized in the Sophia Children*s Hospital or Delft. Older children are expected to have been infected by those viruses and thus have acquired a pre-existing immune response which will influence the level of replication and subsequent shedding. Therefore children > 2 years are excluded from this study. For influenza virus infections: Children in the age range of new-born until five years hospitalized in the Sophia Children*s Hospital or Delft. It has been shown that primary infections with influenza viruses occur later than infections caused by paramyxoviruses. Therefore, children until the age of 5 years are included in this study.
Exclusion criteria
Exclusion criteria: - no written parental informed consent, NB: Co-morbidity is not excluded since we study real-life viral transmission routes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints: Primary end point: Time to negativity of viruses in the nasopharynx compared to infectious airborne virus in the room air. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Endpoints: 1) Particle size of infectious viruses captured by viable impactor air sampling. Particle size will serve as a proxy for route of transmission. 2) Relation between clinical parameters and the load of infectious respiratory viruses in the nasopharynx and air | — |
Countries
Netherlands
Outcome results
None listed