preeclampsia
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Cases consist of women (18 years or older) with preeclampsia (PE) in the current pregnancy (PE is defined as hypertension (systolic blood pressure >= 140 mmHg and/or diastolic BP >= 90 mmHg) developed after 20 weeks of pregnancy with de novo proteinuria (>= 300 mg/ 24 hours)), Controls are women (18 years or older) with an uncomplicated pregnancy (i.e no foetal or maternal placental complications, such as pregnancy induced hypertension, preeclampsia or HELLP-syndrome, or small for gestational birth infancies)
Exclusion criteria
Exclusion criteria: Cases * Women who do not want to be informed about the results of the tests, or women who do not want their general practitioner and specialist(s) to be informed about the test results * Known allergy for iodinated contrast (only if they chose to participate in a track including the CTA measurement) * Known contraindication for the use of betablockers or nitroglycerine Controls * Women with diabetes Mellitus and gestational diabetes * Women with (suspected) IUGR in the current pregnancy (estimated fetal weight p
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The pattern of cardiac recovery (in terms of cardiac geometry, function and miRNA expression) after a preeclamptic pregnancy compared to a normotensive pregnancy. The relation between acute placental atherosis with subclinical coronary atherosclerosis at 12 months pospartum * | — |
Secondary
| Measure | Time frame |
|---|---|
| Lifestyle (questionnaire) Blood Pressure Metabolic syndrome (MetS) Kidney function Glycocalyx thickness (by means of the Glycocheck) Coronary artery calcification (CAC) Carotid Intima media thickness Flow mediated dilation | — |
Countries
Netherlands
Outcome results
None listed