Post-traumatic dysfunction of the innate and adaptive immune system and its relationship with the development of infectious complications in severely injured patients (POSEIDON study)

Post-traumatic dysfunction of the innate and adaptive immune system and its relationship with the development of infectious complications in severely injured patients (POSEIDON study) - POSEIDON-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON53029

Enrollment

100

Registered

2014-02-14

Start date

2014-06-27

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

blood poisoning sepsis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Severely injured trauma patients based on the following criteria: - Severe injury (e.g. AIS > 3) in at least 2 body regions - Physiological disturbances on hospital admission based on: * Heart rate > 100 beats/min, and/or * Systolic blood pressure

Exclusion criteria

Exclusion criteria: - Immunosuppressive medication - Known HIV positive status and related diseases

Design outcomes

Primary

Measure	Time frame
The difference in (anti-bacterial) characteristics of circulating neutrophils between trauma patients who develop sepsis and non-septic patients.	—

Secondary

Measure	Time frame
- The difference in (anti-bacterial) characteristics of circulating neutrophils between trauma patients who develop infectious complications other than sepsis (e.g. pneumonia, meningitis, urinary tract infections, pericarditis, abdominal abscesses, wound infections and fracture related infections) and non-infectious patients. - The difference in (anti-bacterial) characteristics of circulating neutrophils between trauma patients who develop pro-inflammatory complications (e.g. SIRS) and patients who don't develop these complications. - The difference in (inducible) activation status of neutrophils between patients with and without infectious or inflammatory complications	—

Measure

Time frame

- The difference in (anti-bacterial) characteristics of circulating neutrophils between trauma patients who develop infectious complications other than sepsis (e.g. pneumonia, meningitis, urinary tract infections, pericarditis, abdominal abscesses, wound infections and fracture related infections) and non-infectious patients. - The difference in (anti-bacterial) characteristics of circulating neutrophils between trauma patients who develop pro-inflammatory complications (e.g. SIRS) and patients who don't develop these complications. - The difference in (inducible) activation status of neutrophils between patients with and without infectious or inflammatory complications

—

Countries

Netherlands

Outcome results