Autoimmune diseases Rheumatic diseases Rheumatic diseases, Autoimmune diseases
Conditions
Interventions
Not applicable.
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria patients Age 18 years or older (no minors or incapacitated subjects will be included in the study)Ability to understand the patient information form and ability to provide written informed consent.a definite diagnosis of rheumatoid arthritis, systemic lupus erythematosus, ANCA-associated vasculitis, or systemic sclerosis based on current classification criteria, orfulfilment of the current classification criteria for ‘clinically suspect arthralgia’ in the concomitant presence of ACPA in serum, orfulfilment of the current classification criteria for ‘very early SSc’ Written informed consent Inclusion criteria healthy subjects:Age 18 years or older (no minors or incapacitated subjects will be included in the study)Ability to understand the patient information form and ability to provide written informed consent.a self-reported absence of a definite diagnosis of rheumatoid arthritis, systemic lupus erythematosus, ANCA-associated vasculitis, or systemic sclerosis based on current classification criteria or of complaints compatible with the current classification criteria for ‘clinically suspect arthralgia’ or ‘very early SSc’.
Exclusion criteria
Exclusion criteria: Exclusion criteria patients - Individuals who fail to meet the inclusion criteria - Individuals for whom the treating physician considers that relevant safety issues apply (such as, for example, severe anemia) that preclude the provision of 50 ml of peripheral blood. - Individuals who have donated >100 ml of blood (or more) less than two weeks prior to the respective time-point for any reason (such as routine clinical care, participation in another study, blood donations for the blood bank, etc.) Exclusion criteria healthy subjects: - Individuals who fail to meet the inclusion criteria - Individuals who have donated >100 ml of blood (or more) less than two weeks prior to the respective time-point for any reason (such as routine clinical care, participation in another study, blood donations for the blood bank, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Various parameters related to the phenotype and function of auto-reactive B cells. | — |
Countries
Netherlands
Contacts
Public ContactHU Scherer
Leids Universitair Medisch Centrum
Outcome results
None listed