ECT-induced connectivity mechanisms in treatment resistant depression

ECT-induced connectivity mechanisms in treatment resistant depression - ECT-induced connectivity

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52975

Enrollment

100

Registered

2014-08-06

Start date

2015-01-28

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression Major Depressive Disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Males and females between 18-70 years of age • First or recurrent episode of unipolar major depressive disorder, with and without psychotic features (as defined by DSM-IV-TR) • Treatment resistance for at least two antidepressants

Exclusion criteria

Exclusion criteria: • ECT within one year prior to the current course • Use of benzodiazepines within 24 hours before ECT • Presence of a current or past relevant somatic disorder • Presence of comorbid bipolar disorder, schizophrenia or substance abuse disorder • MRI-related exclusion criteria (i.e. claustrophobia, pregnancy, internal metal objects, etc.) • ECT-related exclusion criteria (recent cerebrovascular disease or brain surgery, recent cardiac arrest, unstable angina pectoris (NYHA IV), pheochromocytoma)

Design outcomes

Primary

Measure	Time frame
- changes in functional connectivity in resting state networks as a function of treatment (response) - changes in VTA-related BOLD-signals and habenula-VTA connectivity coding for Temporal Difference Errors in reward/punishment-related learning as a function of treatment (response)	—

Secondary

Measure	Time frame
- changes in structural brain characteristics (cortical thickness, subcortical volumes) as a function of treatment (response)	—

Countries

Netherlands

Outcome results