anesthesie, laparoscopie anesthesia
Conditions
Interventions
Patients in this group will receive deep NMB, aimed at PTC 1-2 during the
entire procedure. The NMB will be maintained with a continuous infusion of
rocuronium and reversed at the end with sugammade
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: ASA 1-3 Age > 18 Scheduled for laparoscopic or robotic abdominal surgery Ability to give oral and written consent
Exclusion criteria
Exclusion criteria: Known or suspected neuromuscular disorders impairing neuromuscular function; Allergies to muscle relaxants, anesthetics or narcotics; A (family) history of malignant hyperthermia; Women who are or may be pregnant; Preexisting cardiac disease (any); Untreated or uncontrolled hypertension; COPD gold 3 or higher Any contradictions for TEE: Preexistent esophageal pathology (stricture, tumor, diverticulum) Any increased risk factor for upper gastro intestinal tract bleed: History of GI surgery; History of GI bleed; Esophageal varices; Gastric or esophageal inflammation; Severe thrombocytopenia (less than 50k) or severely elevated INR (>4).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure at 30 minutes after installation of the pneumoperitoneum | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure at all other time points Left ventricular ejection fraction, stroke volume, systolic and diastolic function, afterload and cardiac output Stroke volume variation Systemic vascular resistance Haemodynamic instability score | — |
Countries
Netherlands
Outcome results
None listed