Cardiac output, cerebral perfusion and cognition in patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation.

Cardiac output, cerebral perfusion and cognition in patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation. - CAPITA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52941

Enrollment

152

Registered

2020-03-05

Start date

2020-08-18

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aortic valve stenosis cerebral pefusion

Interventions

None listed

Eligibility

Age

65 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Presence of severe aortic valve stenosis (aortic valve area 18 years

Exclusion criteria

Exclusion criteria: • Presence of a magnetic resonance imaging (MRI) contra-indication. • Orthopnea or inability to lay flat for 30 minutes • Bodyweight >130 kg • Neurological disease • Insufficient mastery of the Dutch language • Alcohol use >3 units per day or inability to withdraw 24 hours.

Design outcomes

Primary

Measure	Time frame
Cardiac output (L/min), cerebral blood flow (mL/100g/min, change in %, relative to baseline) and cognitive functioning (extensive testing).	—

Secondary

Measure	Time frame
Regional differences in changes in CBF after TAVI (Δ ml/min/m3); Identify patient and procedural characteristics associated with increased cardiac output, CBF, white matter hyperintensity volume and cognitive functioning ; incidence and volume of new white matter hyperintensities after TAVI (number and volume mm3, relative increase %); aortic valve calcification volume (mm3), measured with computed tomography	—

Measure

Time frame

Regional differences in changes in CBF after TAVI (Δ ml/min/m3); Identify patient and procedural characteristics associated with increased cardiac output, CBF, white matter hyperintensity volume and cognitive functioning ; incidence and volume of new white matter hyperintensities after TAVI (number and volume mm3, relative increase %); aortic valve calcification volume (mm3), measured with computed tomography

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Countries

Netherlands

Outcome results