Psychosis
Conditions
Interventions
None listed
Sponsors
University of Maastricht
Eligibility
Age
16 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a participant must meet all of the following criteria: General: • Age range: 16-65 years; • Written informed consent; • MRI compatible (optional) o No metallic implants in the body (e.g., metal braces, metallic teeth filling, pacemaker etc.); o No body tattoos with metallic ink (e.g., colored tattoos may contain metallic ink); o No claustrophobia. Group 1: Individuals recruited from general population who do not hear voices This group includes individuals recruited from the general population who vary from low to high HP based on LSHS scores (university students, participant panels, public advertisement). o No reported history or current diagnosis of any neurological disorder; Group 2: Individuals recruited from general population who hear voices o score on item 8 or 10 of LSHS greater than 0; o score on item 9 should be 0, meaning these individuals are not troubled by the voices; o Item 8: *I often hear a voice speaking my thoughts aloud*; o Item 9: *I have been troubled by hearing voices in my head*; o Item 10: *In the past, I have had the experience of hearing a person*s voice and then found that no one was there; o no reported history or past or current diagnosis presence of any neurological disorder. Group 3: Clinical voice-hearers. This group includes individuals with or without formal diagnosis of psychotic disorder who seek help for their mental health such as at high-risk for psychosis individuals, psychotic patients with past/present AVH experience. o scores on item 9 and 8 and/or 10 of LSHS greater than 0, meaning not only do they hear voices but are also troubled by them; Please note that the categorization of participants is merely for the recruitment purposes and statistical analyses will be based on the continuum perspective. Duration and dosage of any antipsychotic medication will be recorded and used as covariates in the analyses.
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study: o Any previous neurosurgery or neurological disorder, including epilepsy; o Refusing to have EEG performed; o Inability to fully comprehend the purpose of the study or to make a rational decision whether or not to participate; If voice hearing is caused exclusively by substance abuse (drug or alcohol addiction) or a neurological condition such as tumor or lesions etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary effect of interest/study parameter is N100 suppression effect for different types of auditory stimuli obtained during the two EEG experiments, and HP based on the scores of Launay-Slade Hallucination Scale (LSHS). N100 suppression effect will be analyzed as a function of HP scores to examine alterations in sensory feedback and attentional processes associated with voice hearing. | — |
Secondary
| Measure | Time frame |
|---|---|
| In accordance with our secondary objectives, secondary study measures are a) EEG measures (e.g., P200, pre-stimulus alpha power) for self- and externally generated tones vs. neutral self-voice (Experiment. 1), and neutral changing to emotional self-voice in five steps (Experiment.2) using a auditory-motor task b) Resting state EEG measures c) Neuroimaging measures d) Clinical and psychometric variables for the group assignment (voice hearers vs. controls), stratification of the voice hearer group for further exploratory analysis (with vs. without psychiatric diagnosis), as covariates (IQ), listed under *questionnaires* in the research protocol | — |
Countries
Netherlands
Outcome results
None listed