fungal infection of the nail
Conditions
Interventions
1) Miconazole laque, 2) Amorolfine laque, 3) Laque without antifungal effect
(Byte-x).
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - age between 18 and 70 - onychomycosis of one to three townails (per foot) - between 10% and 75% affected area of the nail - matrix of the nail not involved - no 'spikes' of the affected nail
Exclusion criteria
Exclusion criteria: - pregnancy or breast feeding - not able to give informed consent - diabetes - peripheral vascular disease - malignancy - mycosis of the whole foot - allergy to components of the treatments - use of vitamin K antagonists, oral glucose lowering medication, phenytoin. - oral treatment with antifungal medications in the past half year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cure of the index nail after 26 weeks with miconazole or amorolfine compared with non-active laque | — |
Secondary
| Measure | Time frame |
|---|---|
| - percentage of healing (percentage and onycho severity index) - quality of life - side-effects - difference in effect between the three intervention groups | — |
Countries
Netherlands
Outcome results
None listed