Brain Activity During Attempted Movement in Late-Stage ALS: an fMRI Study

Brain Activity During Attempted Movement in Late-Stage ALS: an fMRI Study - Brain Activity in Late-Stage ALS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52876

Enrollment

Registered

2021-03-17

Start date

2022-02-28

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ALS

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Aged 18 or older - Clinical diagnosis of ALS or PLS - No or only minimal and non-functional voluntary movement in the dominant hand - Ability to lie flat on the back for one hour without respiratory difficulties or significant saliva build-up - Oral consent for the willingness to practice tasks at home before the hospital visit (during which formal informed consent will be given; for more info, see section 11) - Reliable communication channel that can be used during the scan for yes-no communication - A score of at least 70% correct on the study understanding questionnaire

Exclusion criteria

Exclusion criteria: - Noncompliance with MRI safety check list - Anxiety in the scanner/claustrophobia - Pregnancy

Design outcomes

Primary

Measure	Time frame
The main endpoint will be the classification accuracy of different movements based on sensorimotor cortex brain activity.	—

Secondary

Measure	Time frame
Whether there are movements that are more easily differentiated based on brain activity, and the effect of late-stage ALS on the brain.	—

Countries

Netherlands

Outcome results