thyroid dysfunction during pregnancy
Conditions
Interventions
None listed
Sponsors
Universiteit van Tilburg
Eligibility
Inclusion criteria
Inclusion criteria: - Pregnant women (18+ y) who have their first antenatal visit
Exclusion criteria
Exclusion criteria: - Multiple pregnancy - Known endocrine disorder before pregnancy - Use of thyroid medication - Severe psychiatric disease (e.g. schizophrenia, borderline, bipolar disorder or depression with known suicidal ideation) - HIV - Drug or alcohol addiction problems - Any other disease resulting in treatment with drugs that are potentially adverse for the foetus and need careful follow-up during pregnancy (e.g. Type 2 Diabetes with use of insulin, Rheumatoid Arthritis with use of prednison or methotrexate, Multiple Sclerosis or Crohn's disease). - No access to internet
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thyroid hormone levels (TSH and fT4) and TPO-Ab and hCG assessed at 12, 20 and 28 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy complications (e.g. pre-eclampsia, pre-term birth, SGA), mode of delivery (spontaneous versus instrumental delivery) and depressive symptoms related to thyroid trajectories and/or poor obstetric outcome. | — |
Countries
Netherlands
Outcome results
None listed