opTimization of timing Window for 18F-FDG PET/CT In patientS with suspecTED prosthetic heart valve endocarditis

opTimization of timing Window for 18F-FDG PET/CT In patientS with suspecTED prosthetic heart valve endocarditis - TWISTED study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52863

Enrollment

Registered

2018-03-20

Start date

2019-05-02

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prosthetic heart valve endocarditis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: > 18 year old The patient underwent prosthetic heart valve implantation.

Exclusion criteria

Exclusion criteria: - hemodynamically unstable patient - (possible) pregnancy - blood glucose levels more than 10 mmol/L - expected inability to lie flat for 1 hour - failure in adhering to the routine pre-scan protocol for suppression of physiological myocardial glucose metabolism

Design outcomes

Primary

Measure	Time frame
Main study parameters: • Visual and quantitative amount of FDG uptake around the prosthetic valve at different time points within 2 hours after FDG injection • Impact of gating on image quality (visual and quantitative assessment) Main endpoints of the study: • Optimal time point for PET/CT image acquisition in patients suspected of prosthetic valve endocarditis • PET/CT Image quality (non-gated vs respiratory and/or ECG gated)	—

Measure

Time frame

Main study parameters: • Visual and quantitative amount of FDG uptake around the prosthetic valve at different time points within 2 hours after FDG injection • Impact of gating on image quality (visual and quantitative assessment) Main endpoints of the study: • Optimal time point for PET/CT image acquisition in patients suspected of prosthetic valve endocarditis • PET/CT Image quality (non-gated vs respiratory and/or ECG gated)

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Countries

Netherlands

Outcome results