premalignant stomach lesion thickening of stomach mucosa
Conditions
Interventions
Patients will be evaluated on separate occasions using standard white-light
endoscopy plus random biopsies (current diagnostic strategy) and the using
enhanced endoscopic imaging with targeted biops
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Participants already in surveillance for premalignant stomach lesions or with new found lesions will be asked to participate in the current study: 1. All patients referred to the endoscopy department for an upper gastrointestinal endoscopy who are found to have chronic atrophic gastritis 2. Patients will be 18 - 75 years old. 3. Patients must be able to give informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with gastric neoplasia not amenable to endoscopic resection. 2. Patients with significant comorbidities 3. Patients with coagulation disorders 4. Patients with previous gastric neoplasia or surgery 5. Being unable to complete the biopsy protocol on either endoscopy session
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy for the endoscopic diagnosis of intestinal metaplasia in different biopsy locations. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Reproducibility of endoscopic staging after expert review 2) Reproducibility of histopathology for detection of intestinal metaplasia 3) Number of dysplastic or neoplastic lesions detected 4) Longer inspection time of gastric mucosa increases accuracy | — |
Countries
Netherlands
Outcome results
None listed