Long-term consequences of more severe COVID-19 infections (complicated respiratory tract infections), in patients managed in general practice and risk factors for a delayed recovery

Long-term consequences of more severe COVID-19 infections (complicated respiratory tract infections), in patients managed in general practice and risk factors for a delayed recovery - PROCOVID-19

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52826

Enrollment

274

Registered

2020-09-04

Start date

2020-09-22

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

respiratory tract infection covid-19

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - At least 18 years of age - History of a complicated respiratory tract infection (ICPC code R81 pneumonia or R02 dyspnea, R05 cough, R74 respiratory tract infection R83 other respiratory tract infection or R78 bronchitis for which a course of antibiotics was started), between March 1st and June 1st 2020 in primary care In order to be eligible to participate in the substudy on neuCD10 expression, a subject must meet all the following criteria: - Positive SARS-CoV-2 study-serology - Written consent to be approached for additional research

Exclusion criteria

Exclusion criteria: - Life expectancy of

Design outcomes

Primary

Measure	Time frame
The main study parameter is the difference in the health-related quality of life (determined by SF-36) between patients with and without an established SARS-CoV-2 infection in a 12 month follow-up period and risk factors that influence recovery.	—

Secondary

Measure	Time frame
Secundairy objectives are to assess in patients who were suspected of having serious COVID-19 infections: differences in the different sections of the SF-36 from index consultation to 12 months after the index consultation, the severity and duration of physical complaints and risk factors that influence recovery, the number of episodes of respiratory infections requiring antibiotic prescription, exacerbations of chronic disorders, hospital referrals, mortality within 12 months, number of contacts with GP, the extent of mental complaints or mental disorders and impact on daily activities. Objectives of the substudy are to assess the presence and severity of long-lasting physical and psychological symptoms after COVID-19 and NeuCD10 expression in blood samples of subjects (using flow cytometry) 24-29 months after a confirmed COVID-19 infection.	—

Measure

Time frame

Secundairy objectives are to assess in patients who were suspected of having serious COVID-19 infections: differences in the different sections of the SF-36 from index consultation to 12 months after the index consultation, the severity and duration of physical complaints and risk factors that influence recovery, the number of episodes of respiratory infections requiring antibiotic prescription, exacerbations of chronic disorders, hospital referrals, mortality within 12 months, number of contacts with GP, the extent of mental complaints or mental disorders and impact on daily activities. Objectives of the substudy are to assess the presence and severity of long-lasting physical and psychological symptoms after COVID-19 and NeuCD10 expression in blood samples of subjects (using flow cytometry) 24-29 months after a confirmed COVID-19 infection.

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Countries

Netherlands

Outcome results