depression, Major Depressive Disorder depression
Conditions
Interventions
All participants will receive two interventions, a mindfulness intervention and
a positive fantasizing intervention. For both interventions, participants will
first receive a professional training f
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: All participants will be between 18 and 60 years of age. Participating patients will have experienced at least two major depressive episodes (experienced in the past ten years) and are in (partial or complete) remission from a depressive episode (for more than 2 months).
Exclusion criteria
Exclusion criteria: Participants should not have any current DSM-5 diagnoses, should currently not use anti-depressant medication (i.e. >4 weeks) have not received protocolized preventive cognitive therapy for their last episode or have recent (daily practice) experiences with mindfulness. Healthy participants should furthermore show no life-time psychopathology.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters of study 1 and 2 concern: i) indices of PC, namely daily fluctuations in self-reported PC (using ESM), reported PC during an experimental task (using SART), physiological correlates of PC (using HR/HRV) and electrophysiological correlates of PC (using EEG). The endpoint of study 1 is within-subject (fantasizing vs. mindfulness) differences in the extent to which PC changes pre- and peri-intervention performance of the interventions as measured with the main study parameters. The endpoint of study 2 is between-group (remitted MDD vs. HC) differences in the extent to which PC changes pre- and peri-intervention performance of the interventions as measured with the main study parameters. The main study parameters of study 3 concern measures of potential individual treatment markers (e.g. PC characteristics, physiological characteristics, personality). The endpoint of study 3 is the correlation between pre-intervention individual characteristics and the efficacy of mindfulness and fantasizing. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters of study 1 concern: i) measures of depressive symptoms and other factors that are potent in being influenced by the interventions (measures with self-report questionnaires: IDS-SR [depressive symptomology], FFMQ [mindfulness], PANAS [positive and negative affect states], LARSS [ruminative thinking on sadness], ERQ [emotion regulation strategies], RPA-NL [ruminative thought in response to positive affect], PTQ [perseverative thinking]) and ii) actigraphy measures reflecting sleep patterns and iii) indices of PC as measured with self-report questions (during SART tasks and ESM), EEG and ICG/ECG (during the SART and emotion regulation). | — |
Countries
Netherlands
Contacts
Public ContactM.J. van Tol
Universitair Medisch Centrum Groningen
Outcome results
None listed