botgezondheid Bone health osteoporosis
Conditions
Interventions
None listed
Sponsors
Hogeschool van Arnhem en Nijmegen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Male and female (18y+) Professional cyclist competing in UCI*s WorldTour competition or a talent of that team. Former professional cyclists (35y+) Willing to give written informed consent. Willing to comply with study procedures.
Exclusion criteria
Exclusion criteria: Having a history of medical events or medication use that may significantly affect bone metabolism, to be decided by the principal investigator. Medication use that may affect tests within this study must be minimal 3 months before Day 01 of this study. Participation in any clinical trial including blood sampling and/or administration of substances up to 30 days before Day 01 of this study A recent injury that may significantly affect BMD, to be decided by the principal investigator. Participants who have had a traumatic fracture recently (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone health: whole body and regional (lumbar spine and femoral hip) bone mineral density and bone mineral content as determined by dual-energy X-ray absorptiometry (DXA). | — |
Secondary
| Measure | Time frame |
|---|---|
| Cycling exercise volume during the preceding 12 months (for retired cyclists we obtain the average volume during a 5 year period in their career). Dietary intake (energy, macronutrients, calcium, vitamin D) Blood parameters of bone health: Procollagen type I N propeptide (PINP), carboxy-terminal crosslinking telopeptide of type I collagen (CTX-I), calcitonine, parathyroid hormone (PTH), testosterone oestrogen. History of sports participation during life. Bone microarchitecture and bone strength will be assessed by HR-pQCT. A scan takes ~2 minutes, is painless, non-invasive and involves only low radiation exposure (effective radiation dose of ~5 µSv). | — |
Countries
Netherlands
Outcome results
None listed