Vascular Phenotypes in a Geriatric Population

Vascular Phenotypes in a Geriatric Population - VARIATION

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52796

Enrollment

150

Registered

2021-07-19

Start date

2022-03-18

Completion date

Unknown

Last updated

2025-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dementia vascular riskfactors

Interventions

None listed

Eligibility

Age

65 Years to 99 Years

Inclusion criteria

Inclusion criteria: - 65 years of age and older - visiting the geriatric memory clinic of the VUmc - signed informed conscent of the general protocol (METc 2017.148)

Exclusion criteria

Exclusion criteria: - Insufficient mastery of Dutch language - Severe cognitive impairment: MMSE-score

Design outcomes

Primary

Measure	Time frame
The main study parameters are different vascular phenotypes, based on measurements of macro- and microvascular function, including intima media thicknes van de common carotic artery, stiffness index of carotid artery, local carotid pulse wave velocity, blood pressure, orthostatic hypotension, glomerular filtration rate, structural brain damage and arterial tonometry. Based on these measurements we aim to distinguish four vascular phenotypes: no vascular damage, both macro- and microvascular damage, only macrovascular damage and only microvascular damage.	—

Measure

Time frame

The main study parameters are different vascular phenotypes, based on measurements of macro- and microvascular function, including intima media thicknes van de common carotic artery, stiffness index of carotid artery, local carotid pulse wave velocity, blood pressure, orthostatic hypotension, glomerular filtration rate, structural brain damage and arterial tonometry. Based on these measurements we aim to distinguish four vascular phenotypes: no vascular damage, both macro- and microvascular damage, only macrovascular damage and only microvascular damage.

—

Secondary

Measure	Time frame
Secondary study parameters are cognitive functioning, as assessed by neuropsychological assessment, physical functioning (handgrip strength, gait speed and Short Physical Performance Battery; SPPB) and functional outcomes: activities of daily living (ADL) and instrumental ADL (iADL) dependence levels, quality of life, (serious) adverse events and mortality.	—

Countries

Netherlands

Outcome results