Non-invasive characterization of paediatric brain tumours using metabolic imaging at high magnetic field

Non-invasive characterization of paediatric brain tumours using metabolic imaging at high magnetic field - MITCH

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52792

Enrollment

Registered

2020-07-31

Start date

2021-03-05

Completion date

Unknown

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

childhood brain cancer Pediatric brain tumors

Interventions

None listed

Eligibility

Age

2 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Children, 6-18 years with a brain tumour, including newly diagnosed patients, patients undergoing active surveillance or patients with a recurrent brain tumor - Children in which tumor will remain in situ and who will undergo at least one of the following treatment strategies: partial tumour resection*, chemotherapy and/or radiotherapy, active surveillance (*wait-and-see*) - Children must be able to undergo MRI without anaesthesia; - Informed and having given informed consent (either by patient and / or parents / legal guardian).

Exclusion criteria

Exclusion criteria: - The presence of claustrophobia; - Patients from who it is expected at the time of inclusion that they will undergo gross/near tumour resection (i.e.

Design outcomes

Primary

Measure	Time frame
Quantified levels of phospholipid metabolites and amide proteins in the tumour compared to healthy brain tissue.	—

Secondary

Measure	Time frame
- Change in phospholipid levels in response to treatment, assessed by 31P- MRSI; - Change in amide protein levels in response to treatment, assessed by APT-CEST; - pH levels of the tissue; - Change in tumour volume: measured on conventional imaging according to RECIST criteria.	—

Countries

Netherlands

Outcome results