Migraine
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Women aged >= 18 years - Menstrual migraine OR Early menopausal transition phase - Migraine frequency: >= 1 attack/month - Regular menstrual cycle with a cycle length between 25-32 days OR LH surge between days 5 and 25 of the menstrual cycle - Normal, mildly increased or decreased BMI
Exclusion criteria
Exclusion criteria: - Insufficient mastery of Dutch - Inability to complete the electronic diary in an accurate manner - Smoking - Chronic migraine - Medication-overuse headache (ICHD-3 criteria) - Women who are breastfeeding, pregnant, or planning to become pregnant - Oral contraceptive use during the last month and not willing to undergo washout period (stop for one month) - Other sex hormone containing treatment use during the last month - Use of corticosteroids during the last month - Anamnestic signs of anemia - Any serious illness that can compromise study participation - Freezer of insufficient quality
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of estradiol during days 8, 10, 12 and 14 after the LH surge | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of progesterone during days 8, 10, 12 and 14 after the LH surge Serum levels of estradiol and progesterone during days 1, 2 and 3 after the LH surge Serum levels of 17-hydroxyprogesterone, testosterone, dihydrotestosterone, androstenedione, DHEA, DHEAS, SHBG, LH, FSH and CGRP during days 1, 2, 3, 8, 10, 12 and 14 after the LH surge. | — |
Countries
Netherlands
Outcome results
None listed