Atrial fibrillation
Conditions
Interventions
OR group: High-resolution cardiac mapping during sinus rhythm, spontaneous or
induced AF before and after applying transcutaneous or invasive LLVS. Blood
sample and tissue biopsy will be obtained du
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: OR group: > 18 years Structural heart disease / coronary artery disease Scheduled for elective cardiothoracic surgery or endovascular cardiac procedures ER / ICU / CCU group: > 18 years Admitted with (ER), or presenting tachyarrhythmia (ICU / CCU) Outpatient clinic group: > 18 years Congenital heart disease / structural heart disease / coronary artery disease Atrial or ventricular ectopy/tachyarrhythmia
Exclusion criteria
Exclusion criteria: OR group: Hemodynamic instability Usage of inotropic agents Emergency cardiac surgeryPrior left sided radiation of the chest for malignancies ER / ICU / CCU group: Hemodynamic instability Paced atrial rhythmsPacemaker/ICDPresence of assist devices Usage of inotropic agents Emergency cardiac surgery Outpatient clinic: Paced atrial rhythms Pacemaker/ICD Hemodynamic instability Presence of assist devices
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The impact of (t-)LLVS on electrophysiological properties such as conduction block and endo-epicardial asynchrony. | — |
Secondary
| Measure | Time frame |
|---|---|
| The effect of (t-)LLVS on incidence and burden of early post-operative AF. To elucidate the correlation between proteostasis marker levels in serum and atrial tissue, and the influence of CANS. To examine the difference between auricular t-LLVS and cervical t-LLVS on atrial electrophysiology. The effect of t-LLVS on termination of tachyarrhythmia The effect of t-LLVS on heart rhythm variability and atrial and ventricular ectopy/tachyarrhythmia in patients with congenital heart disease. | — |
Countries
Netherlands
Contacts
Public ContactN.M.S. Groot
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed