Decoding words with 7 Tesla functional MRI

Decoding words with 7 Tesla functional MRI - Decoding words with 7T fMRI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52733

Enrollment

Registered

2020-08-19

Start date

2020-10-27

Completion date

Unknown

Last updated

2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ALS Amyotrophic Lateral Sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Control group: - Age 18 or older (between 45 - 75 years for the subgroup of controls that will be compared to the patient group, see chapter 4.1 ) - Blank neurological history - Adequate proficiency in Dutch and/or English language Patient group: - Age 18 or older - A diagnosis with bulbar onset ALS or PLS - A strongly impaired ability to speak - Ability to lie flat on the scanner bed for the duration of the fMRI scan (approximately 60 minutes) without respiratory difficulties or significant saliva build-up - Ability to press emergency button in the scanner with the hand - A score of at least 70% on the protocol understanding verification questionnaire - Adequate proficiency in Dutch and/or English language

Exclusion criteria

Exclusion criteria: General: - Noncompliance with MRI safety check list - Claustrophobia - Pregnancy - Inability to hear the instructions presented orally in the scanner without a hearing aid Patient group: - Mechanical ventilation

Design outcomes

Primary

Measure	Time frame
The three study parameters/endpoints are: 1) decoding (classification accuracy) of silently spoken or attempted words from the brain area that represents the articulation of speech in both ALS or PLS patients and healthy controls. 2) The fMRI brain activity pattern related to articulator movements (movement direction and amplitude); 3) The movement trajectories of the articulators during speech production 4) The fMRI brain activity patterns related to the production of phonemes 5) The fMRI brain activity pattern related to different combinations of sequences of the same phonemes within a word.	—

Measure

Time frame

The three study parameters/endpoints are: 1) decoding (classification accuracy) of silently spoken or attempted words from the brain area that represents the articulation of speech in both ALS or PLS patients and healthy controls. 2) The fMRI brain activity pattern related to articulator movements (movement direction and amplitude); 3) The movement trajectories of the articulators during speech production 4) The fMRI brain activity patterns related to the production of phonemes 5) The fMRI brain activity pattern related to different combinations of sequences of the same phonemes within a word.

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Secondary

Measure	Time frame
The secondary study parameters are the optimal acquisition parameters necessary to discriminate different words based on fMRI activity from the brain area representing articulation of speech.	—

Countries

Netherlands

Outcome results