Autoimmunity systemic lupus erythematosus Autoimmunity, systemic lupus erythematosus
Conditions
Interventions
Non-invasive observational study
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: All children from 0-18 years old, with the diagnosis of SLE, fulfilling Systemic Lupus International Collaborating Clinics (SLICC) criteria
Exclusion criteria
Exclusion criteria: - Refusal to participate in the study - Insufficient knowledge of the Dutch language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This is a non-interventional, observational cohort study, in which we aim to standardize the assessment of disease activity in all cSLE patients at baseline visit, during regular outpatient visits and disease flares. For the NP-SLE part of the study: clinical phenotype, MRI abnormalities, EEG patterns, autoantibodies in serum and CSF. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To determine response to treatment - To register adverse events during treatment - To develop prognostic factors by RNA-, DNA-, protein profiling and videocapillaroscopy of the small vessels in the nailfold and under the tongue for monitoring and predicting disease activity, response to treatment and disease flares | — |
Countries
Netherlands
Contacts
Public ContactS.S.M. Kamphuis
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed