Kidney fuNction in people receiving Gender Affirming Hormone Therapy

Kidney fuNction in people receiving Gender Affirming Hormone Therapy - KNIGHT-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52715

Enrollment

Registered

2021-02-22

Start date

2021-09-27

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

het betreft fysiologisch onderzoek kidney function renal physiologie

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Transgender individuals starting gender affirming hormone therapy 18 years or older of age

Exclusion criteria

Exclusion criteria: Iodine allergy use of prescribed medication

Design outcomes

Primary

Measure	Time frame
The main study parameters/endpoints are the measurement of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) as measured by iohexol and p-amminohippurate (PAH) clearance.	—

Secondary

Measure	Time frame
Secondary endpoints are the estimation of intrarenal hemodynamic parameters derived from Gomez equations, markers of tubular injury and changes in systemic hemodynamic properties.	—

Countries

Netherlands

Outcome results