bloodtransfusion packed red blood cel transfusion
Conditions
Interventions
1010 patients undergoing cardiac surgery with cardiopulmonary bypass are
randomized into a group with target ACT >400 seconds or into a group with a
target ACT >480 seconds.
Sponsors
Perfusie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult patients undergoing elective cardiac surgery with cardiopulmonary bypass including coronary artery bypass grafting, valve surgery or a combination of both. Informed consent.
Exclusion criteria
Exclusion criteria: re-operations aorta surgery emergency operation minimized extracorporeal circuits deep hypothermia (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall packed red blood cell transfusion rate during hospitalization. | — |
Secondary
| Measure | Time frame |
|---|---|
| • 12 and 24-hour blood loss assessed by wound drainage • Postoperative hemoglobin values at 1, 12 and 24 hours following surgery • Reoperations due to bleeding • Late tamponade • Transfusion requirements (FFP, platelets, fibrinogen, PCC) • Postoperative hemostatic parameters • Use of preoperative anticoagulant medication • Number of patients who do not reach the target ACT after the first heparin dose • Total heparin and protamine dosing • Postoperative restenosis of grafts • Clotting of the extracorporeal circuit • Thromboembolic events during and following surgery (e.g. venous thrombosis, pulmonary embolism) • Mortality at 30 days, 90 days and 1 year following surgery • Patient demographics | — |
Countries
Netherlands
Outcome results
None listed