Exocrine pancreatic insufficiency impaired exocrine pancreatic function
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Age * 18 years; 2) Written informed consent; 3) Understanding of the Dutch language; 4) Willing and capable of following the instructions for this study; 5) Patients need to be able to achieve a minimal daily dietary fat intake of * 60 grams.
Exclusion criteria
Exclusion criteria: 1) Any known gastrointestinal disease or major gastrointestinal surgery (apart from a PD, esophagectomy, gastrectomy) that could potentially affect the intestinal absorption or metabolism of fat (e.g. short bowel, irritable bowel disease, cystic fibrosis, chronic pancreatitis among others). 2) Gastroparesis of any aetiology (not applicable for group III and IV) . 3) Serious concomitant systemic disorders that would compromise the safety of the patient or his/her ability to complete the study, at the discretion of the treating physician. 4) Patients who are unable to cease anti-diarrheal medication or laxatives, based on the physician*s experience. 5) Patients who are suspected not to be reliable in participating in this study, based on the physician*s experience.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measure is diagnostic accuracy of easy diagnostic test(s) and the presence of steatorrhea-related symptoms to diagnose EPI, compared to the 72-hour faecal fat quantification. | — |
Secondary
| Measure | Time frame |
|---|---|
| - presence of micronutrient deficiencies - incidence of EPI in this patient group - evaluate whether the occurrence of EPI can be predicted based of specific signs and symptoms - evaluate the effect of changes in therapy based on the results of the diagnostic tests included in this study - evaluate the effect of EPI on overall quality of life in postoperative patients | — |
Countries
Netherlands
Outcome results
None listed