Impact of galacto-oligosaccharides on the intestinal microbial composition and -activity: a proof of concept study

Impact of galacto-oligosaccharides on the intestinal microbial composition and -activity: a proof of concept study - Galacto-oligosaccharides and Intestinal Activity / GAIA study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON52662

Enrollment

Registered

2019-06-05

Start date

2020-01-13

Completion date

Unknown

Last updated

2024-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal symptoms

Interventions

Subjects will be randomized into one of the two groups. One group will receive 7.2 grams of GOS supplements tree times daily for four weeks. A second group will receive 7.2 grams of placebo suppleme

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: No gastrointestinal complaints Age between 18 - 50 years BMI between 20 - 30 kg/m2 Willing to be informed in case of unexpected findings

Exclusion criteria

Exclusion criteria: Use of antibiotics within 90 days prior to the study Use of anticoagulation medication (except Ascal) Last colonoscopy within 90 days prior to the study Inadequate or painful (self-reported) colonoscopy undergone in the past American Society of Anesthesiologists (ASA) classification > 2

Design outcomes

Primary

Measure	Time frame
Microbial composition and activity	—

Secondary

Measure	Time frame
Digestive parameters / side effects Metabolite-related genes	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)