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Modulating connectivity with non-invasive brain stimulation during spatial neglect rehabilitation

Modulating connectivity with non-invasive brain stimulation during spatial neglect rehabilitation - Brain modulation during neglect rehabilitation / ModNeglect

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON52644
Enrollment
40
Registered
2020-02-19
Start date
2021-04-09
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obstruction of a blood vessel or bleeding in the brain stroke

Interventions

We will combine an evidence based VST with 30 minutes of (active or sham) dual-site tACS at theta frequency. The intervention is administered 5 times a week for a duration of 2 weeks.

Sponsors

Universiteit Maastricht
Lead Sponsor

Eligibility

Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - 30-80 years of age - Subacute stroke (stroke occurred more than 2 weeks and less than 6 months ago; first or recurrent, ischemic or intracerebral haemorrhagic lesion) - Diagnosed visuospatial neglect and/or spatial neglect symptoms (either left or right sided) on the basis of clinical judgement (i.e. by the cooperating clinical (neuro)psychologist based on intake and neuropsychological assessment). - Sufficient comprehension and communication skills to benefit from training, on the basis of clinical judgement (i.e. by the cooperating clinical (neuro)psychologist based on intake and neuropsychological assessment).

Exclusion criteria

Exclusion criteria: - Physically or mentally unable to participate (e.g. to perform the neglect training) - Severe communicative disability, including aphasia - Local scalp injuries - Eczema on scalp or psoriasis - (Neuro)psychiatric or neurodegenerative diseases including epilepsy (in case patient had one or more seizures in the last 2 years and/or had anti-epileptic medication in the last 2 years), dementia, serious depression, multiple sclerosis, Parkinson*s disease, Huntington*s disease on the basis of clinical judgement (i.e. cooperating (neuro)psychologist) - Current alcohol and/or drug abuse or a history of abuse within the last 6 months - Pregnancy

Design outcomes

Primary

MeasureTime frame
To investigate whether the application of dual-site transcranial alternating current stimulation during cognitive training improves spatial neglect symptoms to a larger extent than the application of sham stimulation during cognitive training.

Secondary

MeasureTime frame
To investigate whether the application of dual-site transcranial alternating current stimulation during cognitive training ameliorates neglect behaviour in activities of daily living (ADL) to a larger extent than the application of sham stimulation during cognitive training.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)