airway obstruction COPD
Conditions
Interventions
Participants will be randomized to either NLPRT or TRT of leg press, shoulder
flexion, calf press and chest press exercises (3 times per week for 8 weeks).
The following will be similar for both the
Sponsors
Merem Medische Revalidatie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) age 40-89 years; 2) Diagnosis of mild to very-severe COPD based on spirometry according the GOLD classification, 3) able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1) patients with asthma as primary diagnosis; 2) neuromuscular skeletal diseases that are unstable and/or that may contribute to exercise limitation or any other contraindications to exercise; 3) currently participating in a structured exercise or pulmonary rehabilitation program or been involved in pulmonary rehabilitation in the past 6 months; 4) experienced a COPD exacerbation in the past 6 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Isotonic strength and endurance: Isotonic maximal strength (1 repetition maximum [1RM]) and endurance test (max number of repetitions performed at 45% of 1 RM) for leg press, shoulder flexion, calf-press and chest-press. | — |
Secondary
| Measure | Time frame |
|---|---|
| unctional performance performance will be evaluated by the endurance shuttle walk test (ESWT) performed in accordance to published guidelines, and reported in meters or seconds. The incremental shuttle walk test (ISWT) will be performed in order to determine the correct walking speed for the ESWT, i.e. 85% ISWT speed. The 60STS test is a reliable, valid and responsive tool for measuring functional exercise capacity in patients with COPD. UULEX test is a reproducible and acceptable exercise that can be used as a simple method to evaluate upper limb function in patients with COPD. Isometric quadriceps strength and endurance will also be performed since the different techniques (isotonic vs isometric) might differ with regard to clinical relevance and responsiveness. Disease-specific health related quality of life will be assessed with the self-administered version of the chronic respiratory questionnaire (CRQ-SA). The CRQ-SA is a widely used disease specific questionnaire to assess symptoms in patients with COPD. The CRQ is valid and responsive to treatment, and has previously been used to evaluate the effects of resistance training and nonlinear periodized exercise training in patients with COPD. The Borg CR10 will be used to quantify the level of dyspnea during exercise training and tests while general dyspnea in daily life will be evaluated using the dyspnea subscale of the CRQ. The total amount of responders i.e. defined as a response over the known minimal detectable change or minimal important difference for included test(s), will be determined and compared. E.g., the minimal important difference after rehabilitation is suggested to be 177 seconds for the ESWT and 3 repetitions for the 60 STS. | — |
Countries
Netherlands
Outcome results
None listed