General Risk factors And iNflammatory Determinants in younger PAtients with copd: the GRANDPA study

General Risk factors And iNflammatory Determinants in younger PAtients with copd: the GRANDPA study - GRANDPA study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON52605

Enrollment

Registered

2019-10-04

Start date

2019-11-11

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD emphysema

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: Inclusion criteria subjects with COPD • Age 40+ years • COPD gold II-IV; FEV 1 10 pack years • Willing and able to comply with the study protocol • COPD diagnosis is based on presence of airflow obstruction (post-bronchodilator spirometry FEV1/ FVC with z-score

Exclusion criteria

Exclusion criteria: • Not full comprehensive in the Dutch language. • A liaison with the coordinating or principal investigator, which could likely influence the decision to participate in this study voluntarily (in concordance with the WMO - article 5) • Other diseases which could influence pulmonary function and/or the immune system such as: o A possible infection of the upper- or lower respiratory tract 6 weeks prior to the collection of materials; o Active malignancy o Lung cancer diagnosis (also in the past) o Asthma as the predominant disease according to the investigator's opinion, a past history of asthma is allowed. o Current pregnancy

Design outcomes

Primary

Measure	Time frame
1a. Cross sectional design To compare the differences in number of inflammatory cells (eosinophils, neutrophils, ILC1 cells, ILC2 cells and cytokines) in blood and sputum in COPD patients and controls during stable disease. 1b. Longitudinal study design To compare the differences in number of inflammatory cells (leucocyte differentiation, ILC1 cells, ILC2 cells and cytokines) in blood during stable disease and exacerbation in COPD patients.	—

Measure

Time frame

1a. Cross sectional design To compare the differences in number of inflammatory cells (eosinophils, neutrophils, ILC1 cells, ILC2 cells and cytokines) in blood and sputum in COPD patients and controls during stable disease. 1b. Longitudinal study design To compare the differences in number of inflammatory cells (leucocyte differentiation, ILC1 cells, ILC2 cells and cytokines) in blood during stable disease and exacerbation in COPD patients.

—

Secondary

Measure	Time frame
2a. Cross sectional study design To measure physiological factors (lung function, activity level) and relate them to inflammatory profile. 2b. Cross sectional study design To study the effect of aging on inflammation, physiology, psychology, quality of life and co- morbidities in COPD.	—

Countries

Netherlands

Outcome results