Immuunsysteem : veroudering gut microbiome Immune system changes
Conditions
Interventions
None listed
Sponsors
Maasstadziekenhuis
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Age 18 - 65 years - Body Mass Index >= 35 with the presence of severe comorbidity related to morbid obesity (diabetes mellitus type 2, obstructive sleep apnoea syndrome (OSAS), hypertension, etc.) or a BMI >= 40 with or without the presence of severe comorbidity related to morbid obesity
Exclusion criteria
Exclusion criteria: - Morbid obesity caused by genetic defects or syndromes - Perioperative conversion to an open approach
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint of this study is to determine whether morbid obesity induces premature T cell aging in circulation T cells and whether bariatric surgery halts or reverses obesity-induced effects on T cells (longitudinal setup with follow-up at 3, 6,12 and 18 months postoperative). | — |
Secondary
| Measure | Time frame |
|---|---|
| - To determine whether obesity-induced premature T cell aging is also present in adipose tissue, muscle tissue and liver tissue obtained during bariatric surgery. - To determine whether the function of the immune system changes after bariatric surgery. - To determine whether the gut microbiome changes after bariatric surgery and to compare the change in the gut microbiome to obese individuals not undergoing bariatric surgery but participating in compared lifestyle intervention. | — |
Countries
Netherlands
Outcome results
None listed