Atelectrauma lung collapse
Conditions
Interventions
All measurements take place on the ICU at the bedside. Patients that require
CMV are included in this study following informed consent.
CMV Baseline (standard of care):
Conventional CMV is set accor
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - The subject is 18 years or older - Informed consent form is signed by the subject or a legal representative - Controlled mechanical ventilation via an endotracheal tube
Exclusion criteria
Exclusion criteria: - Severe sputum stasis or production requiring frequent bronchial suctioning (more than 5 times per nurse shift) - Severe respiratory insufficiency defined as a PaO2 to FiO2 ratio of 15 mmHg) or instable (requiring more sedation or osmotherapy) intracranial pressure - An inner tube diameter of 6mm or less
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoints of this study are lung volume measured by EIT and minute volume measured by the ventilator during either FCV or CMV at the ICU. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints of this study are a comparison of: - Airway pressures (peak airway pressure, mean airway pressure, PEEP) between FCV and CMV. - Lung aeration score with ultrasound between FCV and CMV - Hemodynamic parameters (e.g. mean arterial pressure, heart rate, dose of vasopressors, urine production) between FCV and CMV - Dissipated energy between FCV and CMV - Safety of FCV | — |
Countries
Netherlands
Outcome results
None listed